Joker: Folie a Deux menceritakan tentang Arthur Fleck (Joaquin Phoenix) yang ditahan di Arkham sambil menunggu persidangan atas kejahatannya sebagai Joker. Sambil berjuang dengan identitas gandanya, Arthur tidak hanya menemukan cinta sejati (Lady Gaga), tetapi juga menemukan musik yang selalu ada di dalam dirinya.
The only weakness of Joker: Folie à Deux is that its foundation and script rely heavily on the first film. Viewers who have forgotten the first movie may feel "lost." However, the musical element is a beautiful differentiator, though one song sequence feels out of place with what the film is trying to convey. That said, the film is still rich in symbolism, with a precise script and solid performances. The cinematography is stunningly beautiful and full of symbolic meaning. Ultimately, this film is about the Joker—an alternate personality of Arthur Fleck, who has been shared not just with Harley Quinn but with everyone who supports him, including one particularly "dangerous" person who delivers an unsettling joke at the end. The musical serves as the vehicle for spreading this madness.