Gru dan Lucy serta anak-anak perempuan mereka—Margo, Edith, dan Agnes —menyambut anggota baru di keluarga Gru, Gru Jr., yang bertekad untuk menyusahkan hidup sang ayah. Gru menghadapi musuh baru, yaitu Maxime Le Mal dan pacar femme fatale-nya, Valentina, sehingga keluarga mereka terpaksa melarikan diri.
If there are any 25 films about Gru's family and the minions, I will encourage myself to stop watching it starts from #DespicableMe4. Because this sequel is feels forced, dry, and not really funny anymore. Too much spoof in one film feels like this one is trying to win audience hearts but failed to entertained. One of the worst this year